| NÚMERO | EMPRESA | LOCALIDAD | VENTAS 2021 | VENTAS 2022 | Estrategia Digital |
| 1 | EL POZO ALIMENTACION SA | ALHAMA DE MURCIA | 1.445.828.435,00€ | 1.662.528.856,00€ | https://megaseo.es/?p=12189&preview=true&_thumbnail_id=12190 |
| 2 | HERMANDAD FARMACEUTICA DEL MEDITERRANEO S.C.L. | SANTOMERA | 1.371.753.000,00€ | ||
| 3 | REGULADORA DE COMPRAS DEL MEDITERRANEO SA | SANTOMERA | 1.334.305.397,00€ | 1.463.776.877,00€ | |
| 4 | EVIOSYS EMBALAJES ESPAÑA SA. | LAS TORRES DE COTILLAS | 589.146.935,97€ | 684.092.399,26€ | |
| 5 | PC COMPONENTES Y MULTIMEDIA SLU | ALHAMA DE MURCIA | 564.749.551,67€ | 519.357.822,55€ | |
| 6 | PRIMAFRIO SLU | ALHAMA DE MURCIA | 489.346.434,00€ | 577.755.907,53€ | |
| 7 | CEREALES Y HARINAS GARSAN SL | LORCA | 422.868.852,60€ | 526.920.996,84€ | |
| 8 | SABIC INNOVATIVE PLASTICS ESPAÑA S COM P A | LA ALJORRA | 367.565.319,00€ | 532.120.681,00€ | |
| 9 | CEFU SA | ALHAMA DE MURCIA | 365.414.965,00€ | 477.671.422,00€ | |
| 10 | SOLTEC ENERGIAS RENOVABLES SLU | MOLINA DE SEGURA | 355.406.044,00€ | ||
| 11 | AMC NATURAL DRINKS, SOCIEDAD LIMITADA. | ESPINARDO | 337.237.019,23€ | 395.804.697,00€ | |
| 12 | GARCIA ARANDA SL | LIBRILLA | 334.300.675,02€ | 374.217.499,52€ | |
| 13 | EUROPAMUR ALIMENTACION SA | CHURRA | 293.912.376,18€ | 313.069.943,32€ | |
| 14 | GP LIMITE ANDAMUR SL | LORCA | 281.588.065,14€ | 441.944.053,43€ | |
| 15 | JUAN JIMENEZ GARCIA SA | LORCA | 257.932.637,36€ | 324.691.742,06€ | |
| 16 | AGRONATIVA SL | CIEZA | 214.233.912,25€ | 200.345.389,66€ | |
| 17 | DEPAU SISTEMAS SL | CARTAGENA | 207.741.961,66€ | 192.274.542,38€ | |
| 18 | ECOCARBURANTES ESPAÑOLES SA | CARTAGENA | 203.267.000,00€ | 256.411.000,00€ | |
| 19 | ENERGYWORKS CARTAGENA SL | CARTAGENA | 201.289.071,00€ | 342.785.732,00€ | |
| 20 | AUXILIAR CONSERVERA, SA | MOLINA DE SEGURA | 180.799.559,74€ | 247.901.966,14€ | |
| 21 | DIEGO LOPEZ LOPEZ SL | ALMENDRICOS | 175.765.706,64€ | 223.243.393,21€ | |
| 22 | HERO ESPAÑA SA | ALCANTARILLA | 172.851.001,00€ | 200.955.426,00€ | |
| 23 | ZAMORA COMPANY GLOBAL SL. | CARTAGENA | 170.497.713,00€ | 195.806.682,00€ | |
| 24 | LINEAGE SPAIN TRANSPORTATION SL. | LAS TORRES DE COTILLAS | 166.467.225,00€ | ||
| 25 | LA COMARCA MEATS SLU | LORCA | 157.393.361,46€ | 202.674.019,88€ | |
| 26 | NAGARMUR SL | MURCIA | 155.213.066,27€ | 159.528.213,59€ | |
| 27 | FRUCA MARKETING S.L.U. | BALSAPINTADA | 152.368.494,90€ | 141.229.708,71€ | |
| 28 | GOR FACTORY SA | FORTUNA | 151.835.647,71€ | 224.017.827,94€ | |
| 29 | RECURSOS ENERGETICOS DEL SURESTE SL. | FORTUNA | 146.031.465,63€ | 187.092.436,36€ | |
| 30 | MOYCA GRAPES SL. | TOTANA | 144.276.718,00€ | ||
| 31 | FRUIT TECH NATURAL SA | ESPINARDO | 138.965.558,96€ | ||
| 32 | FINI GOLOSINAS ESPAÑA SLU | MOLINA DE SEGURA | 133.316.074,35€ | 183.107.325,60€ | |
| 33 | MOSCA-MARITIMO SL | MOLINA DE SEGURA | 133.148.552,97€ | ||
| 34 | VIDAL GOLOSINAS SA | MOLINA DE SEGURA | 132.472.592,75€ | 189.478.161,50€ | |
| 35 | CULMAREX SAU | AGUILAS | 131.491.851,00€ | 157.976.932,00€ | |
| 36 | VINOS Y LICORES GAMBIN SL | LORQUI | 130.379.519,54€ | 136.508.645,19€ | |
| 37 | FUENTES FERTILIZANTES SL. | TOTANA | 128.000.700,89€ | 183.603.081,96€ | |
| 38 | SOLPLAST SA | LORCA | 127.862.307,51€ | 134.241.850,56€ | |
| 39 | MARVIMUNDO SLU | ALGUAZAS | 124.374.494,29€ | 136.911.087,19€ | |
| 40 | AGRUPACION HORTOFRUTICOLA LUCAS O.P.F. H. SOCIEDAD LIMITADA. | ESPINARDO | 124.366.317,00€ | 136.095.933,00€ | |
| 41 | HERMANOS INGLES SA | POZO ESTRECHO | 123.287.359,42€ | 118.401.812,03€ | |
| 42 | FRIPOZO SA | LAS TORRES DE COTILLAS | 123.285.612,00€ | 159.277.375,00€ | |
| 43 | FRANCISCO ARAGON SLU | MOLINA DE SEGURA | 122.906.811,81€ | 124.438.935,75€ | |
| 44 | TRANSPORTES EL MOSCA SA | MOLINA DE SEGURA | 122.787.041,81€ | ||
| 45 | ZAMORA COMPANY ESPAÑA, S.L. | CARTAGENA | 120.439.662,00€ | 139.271.918,00€ | |
| 46 | LIWE ESPAÑOLA, SA | PUENTE TOCINOS | 120.222.885,00€ | 124.125.798,00€ | |
| 47 | BOVI SA | LAS TORRES DE COTILLAS | 118.613.873,82€ | ||
| 48 | GRUPO UPPER S.COOP. | CARTAGENA | 116.935.545,96€ | 129.027.985,32€ | |
| 49 | GERIMPORT SL | BENIAJAN | 112.451.980,75€ | 141.650.067,13€ | |
| 50 | CROWN PACKAGING MANUFACTURING SPAIN, SOCIEDAD LIMITADA. | LAS TORRES DE COTILLAS | 109.902.537,14€ | 129.719.636,35€ | |
| 51 | LIMCAMAR SOCIEDAD LIMITADA | EL PUNTAL | 109.825.856,00€ | 110.711.763,00€ | |
| 52 | A.T. LA ESPADA S.L. | MURCIA | 108.380.707,31€ | 136.998.062,53€ | |
| 53 | JUVER ALIMENTACION SL | CHURRA | 107.725.305,00€ | 120.607.405,00€ | |
| 54 | PLAY ORENES SL | MURCIA | 106.570.919,00€ | 138.064.750,00€ | |
| 55 | EVERSIA SA. | MOLINA DE SEGURA | 106.077.243,51€ | 122.980.788,17€ | |
| 56 | AZOR AMBIENTAL SA | MOLINA DE SEGURA | 105.859.991,00€ | 117.477.775,00€ | |
| 57 | N. 9895 AGRICOLA PERICHAN S.A.T. | MAZARRON | 104.861.633,66€ | 115.944.782,53€ | |
| 58 | ULTRACONGELADOS AZARBE SA | EL RAAL | 104.540.572,59€ | 111.611.140,97€ | |
| 59 | TSI PLUS SL | MURCIA | 102.880.542,00€ | 105.036.447,51€ | |
| 60 | GROUP REINA MERCADO GLOBAL SL. | CARAVACA DE LA CRUZ | 102.109.060,26€ | 54.050.088,92€ | |
| 61 | PASCUAL MARKETING SL | TORRE-PACHECO | 101.148.072,00€ | 107.185.907,00€ | |
| 62 | ZUKAN SL | MOLINA DE SEGURA | 100.617.875,98€ | 133.919.362,79€ | |
| 63 | AGROMEDITERRANEA HORTOFRUTICOLA SL | DOLORES | 100.567.336,00€ | 102.372.237,00€ | |
| 64 | TRANSPORTES GRUPO CALICHE SL | SAN JAVIER | 100.223.426,43€ | 122.473.055,34€ | |
| 65 | RICARDO FUENTES E HIJOS SA | CARTAGENA | 99.311.430,96€ | 116.819.326,48€ | |
| 66 | INTEREMPLEO EMPRESA DE TRABAJO TEMPORAL S.L. | 96.249.280,41€ | 85.937.624,61€ | ||
| 67 | HIJOS DE JUAN PUJANTE SA | MURCIA | 95.959.796,00€ | ||
| 68 | RAMON SABATER SAU | MURCIA | 95.589.169,00€ | 116.398.117,00€ | |
| 69 | PLASBEL PLASTICOS SAU | ALCANTARILLA | 94.407.418,08€ | 105.601.653,00€ | |
| 70 | ETOSA OBRAS Y SERVICIOS BUILDING SL. | TOTANA | 93.548.109,67€ | 112.245.786,99€ | |
| 71 | CENTRAL QUESERA MONTESINOS SL | JUMILLA | 93.536.985,87€ | 103.875.865,12€ | |
| 72 | FRUTAS ESTHER SA | ABARAN | 89.967.030,00€ | 83.705.634,00€ | |
| 73 | HIERROS IBAÑEZ SA | SAN GINES | 89.506.622,42€ | 95.806.563,95€ | |
| 74 | IBERCHEM SA | ALCANTARILLA | 88.932.032,00€ | 102.690.778,00€ | |
| 75 | HUERTAS MOTOR SL | CARTAGENA | 88.669.203,01€ | 103.731.795,20€ | |
| 76 | POSTRES Y DULCES REINA SL | CARAVACA DE LA CRUZ | 87.232.162,14€ | 111.044.430,28€ | |
| 77 | PRAMAC IBERICA SA | BALSICAS | 86.979.131,00€ | 99.335.513,00€ | |
| 78 | GRUPO HORTOFRUTICOLA PALOMA SA | MAZARRON | 83.852.660,00€ | 98.363.680,00€ | |
| 79 | HIDROGEA GESTION INTEGRAL DE AGUAS DE MURCIA SOCIEDAD ANONIMA. | MURCIA | 82.880.000,00€ | ||
| 80 | FRUVECO SA | EL RAAL | 82.455.995,01€ | 103.632.391,22€ | |
| 81 | JAKE SA | MOLINA DE SEGURA | 81.465.556,39€ | 104.386.429,74€ | |
| 82 | PORCISAN SA | SANTOMERA | 80.582.794,12€ | 101.983.603,58€ | |
| 83 | SURESTE SEGURIDAD SL | MOLINA DE SEGURA | 79.967.583,34€ | 93.001.929,96€ | |
| 84 | SERMUCO S.COOP. DE 2 GRADO | LORQUI | 78.246.471,92€ | 102.192.618,88€ | |
| 85 | ALMACENES BEMALU SA | MAZARRON | 78.114.770,57€ | 87.724.678,77€ | |
| 86 | INDUSTRIA JABONERA LINA SAU. | LAS TORRES DE COTILLAS | 77.714.586,04€ | 84.193.916,42€ | |
| 87 | EMPRESA MUNICIPAL DE AGUAS Y SANEAMIENTO DE MURCIA SA | MURCIA | 75.607.371,13€ | 79.094.760,94€ | |
| 88 | XTI FOOTWEAR SL | YECLA | 75.076.606,17€ | 120.152.061,98€ | |
| 89 | PLASTICOS DEL SEGURA SL | BENIAJAN | 74.963.243,62€ | 87.401.432,38€ | |
| 90 | SONIFER SA | MURCIA | 74.681.224,30€ | 69.289.098,63€ | |
| 91 | ORGANIZACION DE PRODUCTORES AGROMARK SL | DOLORES | 73.798.550,51€ | 72.718.989,42€ | |
| 92 | PREZERO SERVICIOS URBANOS DE MURCIA SA. | SAN GINES | 73.487.000,00€ | 77.485.000,00€ | |
| 93 | DZ LICORES SL | CARTAGENA | 72.976.285,00€ | 96.407.780,00€ | |
| 94 | ESTRELLA DE LEVANTE FABRICA DE CERVEZA SA | ESPINARDO | 72.190.817,50€ | 85.402.445,07€ | |
| 95 | STV GESTION SL | TORRE-PACHECO | 69.865.414,58€ | 84.134.328,51€ | |
| 96 | HISPAVIMA SL | LA CATEDRAL | 67.843.879,73€ | 8.769.570,32€ | |
| 97 | GARAJE LA HOYA SL | LORCA | 67.333.215,71€ | 100.417.506,87€ | |
| 98 | CASH LEVANTE SL | EL PALMAR O LUGAR DE DON JUAN | 67.279.024,20€ | 88.010.437,14€ | |
| 99 | SOL Y TIERRA CAMPO DE CARTAGENA SL | SAN CAYETANO | 66.729.126,44€ | ||
| 100 | SAT NUMERO 9 . 821 GRUPO CFM | EL ESTRECHO | 66.139.630,26€ | 69.905.182,46€ |
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